In a world where Reapers prey on the souls of the living, imprisoning them in the shadow-land of Mortem, there is one last hope for humanity. Her name is September Mourning. Half human, half Reaper, she takes the souls of the wicked so the innocent can live again. September has joined forces with a woman who was murdered and restored to life, and a young blind girl who sees only the dead. Together, as The Trinity, they set out to fulfill a prophecy...

The Final Battle is approaching and Heaven needs new recruits. Zera sets out to find God, because only He can set the Rapture in motion. If Spawn is going to prevent the Apocalypse, this looks like his last chance.

Wanda's family is torn apart as Spawn bares his heart to Cyan... Literally! And Granny Blake gains her reward for living a virtuous life in the service of God. She is among the pure souls chosen for the Rapture. The one thing she didn't expect was to find that Heaven has become a War Zone and she's on the front line.

In the depths of hell Spawn faces torture at the hands of The Grand Inquisitor Thamuz, who has sworn to uncover Spawn's deepest secret or tear his soul apart trying. Meanwhile a thirteen-year-old boy is sent on a simple quest, unaware that the fate of mankind lies in his hands.

"A Tale of Three Brothers" continues as Al Simmons becomes a cold-blooded killer, while his brothers follow their own paths, one to become a man of justice, the other descending into drug addiction and mental breakdown. As the memories flood back, Spawn begins to realize that it was no accident that he was chosen to become a Hellspawn.

The end of an era. When Al Simmons was murdered, he made a deal with the demon Malebolgia and became a Hellspawn so that he could return from the grave. Now he faces death once again and this time there is nothing that can save him from the jaws of Hell.

Just what is up with those twins? Things get seriously out of hand and Spawn is forced to break off his battle with Kali when he senses that Wanda's life is in danger. Elsewhere, Zera forms a new alliance. God is not in his heaven and all is wrong with the world.

With Spawn revitalized, it's time to take his pounds of flesh from those who have imprisoned and tortured him. A battle royal of classic proportions in the bowels of Hell itself with Spawn's most vile villains! And meanwhile, all is not right at the Fitzgerald's. The twins are behaving very strangely....

Issue 165 breaks continuity and features a Mandarin Spawn one-shot. Lan Medina, part of the Eisner award-winning team on Fables, is doing the art honors. The Mandarin Spawn action figure has long been a fan favorite, and in response to their requests over the years, this issue provides the origin of the character.

Spawn faces his greatest challenge -_ The Disciple. Armageddon is approaching fast and with Heaven's new recruits lining up for battle, Hell is going to need to swell its ranks too. And where is it going to find the cruelest, most ruthless, kick-ass SOB's on the face of the Earth? Burn, Hollywood, BURN!